KYAN Technologies,Alentis Therapeutics,and CELLphenomics Join Forces Combining Cutting-edge Optim.AI™ and PD3D® Models to Advance Claudin-1 Expression Research
KYAN Technologies, a vanguard combinatory drug development solutions provider, is thrilled to announce a strategic partnership with Alentis Therapeutics, a clinical-stage biopharmaceutical company developing breakthrough treatments for Claudin-1 positive tumours and organ fibrosis. This partnership aims to accelerate research into Claudin-1 expression using innovative patient-derived 3D (PD3D®) cell culture models provided by CELLPhenomics.
Claudin-1 (CLDN1) is a member of the tight junction protein family. In many solid tumours and during organ fibrosis CLDN1 is overexpressed and exposed outside of tight junctions, where it plays a key role in disease pathogenesis. Alentis is rapidly advancing a clinical pipeline of antibodies specifically targeting exposed CLDN1, unlocking a new mode of action to treat cancer and reverse fibrosis.
Through this collaboration, all three organizations will leverage their respective expertise and resources to advance Claudin-1 expression research to new heights. KYAN Technologies will bring its cutting-edge Optim.AI™ platform, a revolutionary technology that employs small data AI and experimentally derived datasets. Optim.AI™ solves large and complex search spaces to identify and rank combination treatments across the spectrum of biological models. Alentis Therapeutics will contribute its extensive experience in disease research and drug development, while CELLPhenomics, a renowned provider of complex patient-derived cell culture models will provide hyper-characterized models tailored specifically for CLDN1 expression studies and subsequent compound screening.
This exciting research partnership enables more precise and detailed insights into the role of CLDN1 in cancer, paving the way for novel therapeutic approaches.
Mr Hugo Saavedra, CEO of KYAN Technologies, expressed enthusiasm about the partnership, saying, “We are thrilled to have a strategic alliance with CELLphenomics and work together to support Alentis as we all strive to pave the way for better cancer care. This is an opportunity to leverage our Optim.AI platform in a powerful union to accelerate the development of novel therapies that can provide meaningful benefits to patients suffering from cancer and fibrotic diseases.”
Alberto Toso, SVP Head of Oncology at Alentis Therapeutics, added, “We are pleased to partner with KYAN Technologies and CELLphenomics in our pursuit of developing novel Claudin-1 targeting therapies to treat cancer. We eagerly await the results from the experiments using state-of-the-art patient-derived cell models and the AI platform to inform our development efforts.”
Dr. Christoph Reinhard, CSO of CELLphenomics added, “It is critical to have disease-relevant models such as our proprietary PD3D® models for an ambitious project like this one. Our combined technologies yield more than a half million possible results per experiment. You simply cannot unlock the power of AI with the classic existing models such as generic cell lines or PDX when it comes to clinical utility.”
The scientific and medical communities can anticipate groundbreaking discoveries and novel insights into CLDN1, which represents a significant step forward in the pursuit of improved treatments to benefit patients with CLDN1+ tumours worldwide.